Two systematic reviews of SARS-CoV-2 vaccines were found by our searches (Table 13, Table 14). The first (3) was published in May 2020 with searches completed April 17, 2020. At that time, only one trial of an mRNA vaccine was found, and results of it had not been reported. The second systematic review (4) has not been peer-reviewed and published, but a preprint of the authors’ manuscript was posted to the medRxiv server on November 4, with searches completed on October 20. Five trials were meta-analyzed in this review, but only one of them (5) involved an mRNA vaccine. That trial was very small, and while it found a higher rate of adverse events in the vaccine group than in the placebo group, that difference was not statistically significant. All of the reported adverse events were minor, most were localized, and all resolved within days.
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