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I won't elaborate about gun shot wounds but will say a 22 will penetrate deeper than say a 32 or even a 380 . I remember as a young fellow seeing a demostration on gun safety seeing a 22 long rifle going through 6 3/4 " wide pine boards that were seperated by about 2 inchs and lodging in the...

At 50 yards with a 45 I would have better luck throwing a baseball or the pistol as to shoot it . I'd be lucky to hit lake Erie from a row boat . Put a stock on it and a long barrel,the game changes in my favor .;)

You have to remember that a .45 ACP puts all that shock into the target . They are not known for either accuracy nor penetration but they most likely could knock down about anything if it were close enough . If I recall correctly from my navy days that round in a pistol had an effective range...